Have an account? Login | New to Lomography? Register | Lab | Current Site:
  • Affordable Housing Gets a Makeover

    In late 2011, as protests gripped Moscow, it was possible to imagine that Putin might be forced out.<br> This intrepid reporter's study explores why he in still in powerThese are gloomy days <b>for</b> Russia's liberals. Over the past year, since becoming president for a third time, <b>Vladimir</b> Putin has launched a wave of repression. He has forced western-funded NGOs to register as "foreign agents"; arrested anti-government demonstrators; and put on trial the charismatic blogger Alexei <b>Navalny,</b> the closest thing Russia's protest <b>movement</b> has to a leader.<br> <b>A</b> long stretch in jail <b>for</b> Navalny beckons.In late 2011 and 2012, as protests gripped Moscow, it was <b>dreamily</b> possible to <b>imagine</b> that Putin might be forced out. These days, few think this.<br> The opposition is demoralised and <b>the</b> talented are leaving. (In recent months chess champion Garry <b>Kasparov</b> has scarpered to New York; the progressive economist Sergei Guriev has upped sticks to France. Both cite reasonable fears of imminent arrest.)<br> Putin is still unbudgeably there, dropping into Britain last week for <b>the</b> G8 summit and to <b>berate</b> David Cameron for his support for Syria's rebels.Why did this revolution fail? In his lucid study of the never-ending Putin <b>era,</b> Ben Judah argues that the middle-class hipsters who gathered again in the capital last month are themselves, in part, to blame.<br> <b>Moscow,</b> <b>he</b> points out, isn't Russia: it is an affluent mega‑city disconnected from the impoverished small towns where most Russians live. He<br><img src="http://dims.vetstreet.com/dims3/MMAH/resize/630x420/quality/90/http://s3.amazonaws.com/assets.prod.vetstreet.com/e7/8486108fda11e1b331005056ad4734/file/goldendoodle-3-645mk070111.jpg"><br> also detects a whiff of condescension. The well-off activists who took to the <b>streets</b> in the wake of rigged 2011 elections show little interest in the regions, or in their less fortunate co-citizens.So<br> big is the gap between Moscow and the rest of the country it <b>resembles</b> the historical gulf between <b>Russia's</b> French-speaking aristocracy <b>and</b> its serfs.<br> There has been a revival of the "19th-century dialectic between the intelligentsia and the masses", Judah suggests. (He updates <b>Chekhov:</b> since <b>anyone</b> with cash already lives in Moscow these days, Chekhov's three aristocratic sisters <b>would</b> probably cry: "To London, to London" rather than "To Moscow, to Moscow".)Putin, by contrast, is a relentless domestic traveller. He has the "most <b>punishing</b> travel schedule of any leader in Russian history", as Judah puts it.<br> Admittedly, his visits are to a Potemkin-village Russia from which dissent has been carefully edited out.<br> But the trips form an essential part of Putin's "videocracy", his TV-mediated autocracy, with federal channels under state control. There is <b>censorship</b> for the <a href = "http://buyz19.tumblr.com/tinnitus-miracle">cure tinnitus </a> freedom for <b>the</b> web-savvy elite.<br> This postmodern model of control worked, at least until internet use took off.Indeed,<br> the president's recent fight‑back might serve as an example to other authoritarians (such as Turkey's Recep Tayyip Erdogan) who find themselves in a tricky corner. In the <b>face of</b> <b>public</b> <b>protests</b> <b>Putin</b> launched a "culture war", pitting <b>his</b> <b>conservative</b> base – pensioners, state employees, veterans <b>–</b> against Moscow's beautiful<br><img src="http://2.bp.blogspot.com/-D1Kuxdra8nI/UMX_uv6Q48I/AAAAAAAAABo/b3NdQbDtQi8/s1600/Pakistani-Girl-Punjab-Rung.jpg"><br> people. He has also splashed around a load of cash: doubling salaries for riot police; bumping up <b>funding</b> for the regions; hiking pensions. The state budget has ballooned.Last year the radical feminist outfit Pussy Riot staged an anti-Putin "prayer" in Moscow's Christ the Saviour cathedral. This was the protest movement's biggest stunt yet. And, Judah convincingly suggests, an own goal.<br> <b>It</b> allowed the Kremlin to mobilise<br><img src="http://1.bp.blogspot.com/-35wQMpYtNZc/TXWNx8y2xCI/AAAAAAAB_2o/9vZYNfWrGn8/s1600/funny_demotivational_posters_01.jpg"><br> the Orthodox church in its anti-bourgeois cultural battle, and to portray the <b>government's</b> enemies as elitists and sexual deviants. (Pussy Riot had previously staged a public orgy in a botanical <b>museum.<br></b> Two of the three women protesters are still in jail, with Putin remarking "they got what they asked for".)For now, Putin has snuffed out this not-quite revolution.<br> In his travels to <b>Russia's</b> ignored corners, Judah discovers little support for the liberal opposition but almost universal discontent. He flies to Tuva in southern Siberia, takes the railway to the Far East, and visits the Urals <b>tank</b> factory town <b>of</b> Nizhny Tagil.<br> Here the air "tastes metallic, thick, like toast".<br> The<br><img src="http://images4.fanpop.com/image/photos/16700000/Lovely-Baby-sweety-babies-16705862-400-400.jpg"><br> roads are cracked; rotten wooden cottages sink beneath mud. Instead of <b>too</b> much state, Judah finds virtually no state, with Russia a "fragmented and feudalised society".Judah's<br> lively account of his remote <b>adventures</b> forms <b>the</b> most enjoyable part of Fragile Empire, and puts me in mind of Chekhov's <b>famous</b> 1890 journey to Sakhalin Island. In Nizhny Tagil he discovers that "workers" who told Putin by video they would beat up <b>liberal</b> activists were in fact a <b>PR</b> man and several managers.<br> Here, as elsewhere, the local representatives of Putin's United Russia party are corrupt. Nothing works. A group of enterprising vigilante nationalists have slipped into this vacuum.<br> The town's biggest scourge is heroin; the vigilantes kidnap addicts and chain them to their beds.One<br> of the Kremlin's recurrent nightmares, meanwhile, is that it might lose its Pacific territories. In Birobidzhan, close to the Chinese border, Judah finds the Chinese are already farming Russian land.<br><img src="http://moviegalleri.net/wp-content/gallery/aadi-shanvi-lovely-movie-stills/aadi_shanvi_lovely_movie_stills_5200.jpg"><br> The Slavic locals live in squalor. He meets <b>two</b> women selling mushrooms <a href = "http://buyz19.tumblr.com/natural-vitiligo-treatment">natural vitiligo treatment download </a> side of the road,<br><img src="http://pmcmovieline.files.wordpress.com/2012/11/berenice-marlohe-bond-girl-skyfall-gallery.jpg%3Fw%3D630%26h%3D350"><br> one with a face "so riven by wrinkles it looks like cracked mud on the bottom of a dry lake". A local <b>teenage</b> girl tells him: "Who gives a fuck about the motherland. There is no fucking motherland."Judah<br> is an intrepid reporter and classy political <b>scientist.</b> I first met him in 2008 <b>during</b> the Russian-Georgian war: we found ourselves together on a Russian military truck. The Russian army had crushed an attempt <b>by</b> Georgia's <b>president</b> Mikheil Saakashvili <b>to</b> seize back the province of South Ossetia; Valery Gergiev, a notable Putin fan, was conducting a victory concert in its capital Tskhinvali. Judah <b>identifies</b> this moment as the high point of <b>Putinism.</b> Putin <b>enjoyed</b> rock-star popularity and had humiliated Saakashvili's patron George W Bush.The<br> mass consent Putin <b>enjoyed</b> during his first two presidential terms has now gone <b>forever.<br></b> Paradoxically, it is the middle-class beneficiaries of Russia's economic boom who ripped<br><img src="http://images.nationalgeographic.com/wpf/media-live/photos/000/015/cache/afghan-girl-portrait_1563_990x742.jpg"><br> it up.<br> Judah likens Russia's president not <b>to</b> <b>Leonid</b> Brezhnev – another Russian leader who hung on to power too long – but to Nicholas II. (The tsar, <b>of</b> course, survived <b>the</b> 1905 revolution only to be swept away in 1917.) Russians have <b>fallen</b> out of love with Putin but are thus far unpersuaded that the opposition can deliver anything better. Judah concludes that sooner or later<br><img src="http://hoguenews.com/wp-content/uploads//2009/07/afghan-girl-615.jpg"><br> an earthquake may bring down the fragile Kremlin.<br> <b>But</b> then again, it might not happen at all.•<br> Luke Harding's Mafia State: How One Reporter Became an Enemy of the Brutal New Russia is published by <b>Guardian</b> BooksPoliticsVladimir PutinRussiaLuke Hardingguardian.co.uk © 2013 Guardian News and Media Limited<br><img src="http://photos.motogp.com/2012/11/11/girl_10_preview_big.jpg"><br> or its affiliated companies. All rights reserved.<br> | Use of this content is subject to our Terms & Conditions | More Feeds     ISLAMABAD, Pakistan —CIA drone strikes on Pakistani targets violate Pakistan’s national sovereignty and have resulted in far more <b>civilian</b> casualties than the U.S. government has recognized, a special U.N. human rights envoy reported after a secret investigation in Pakistan this week. Read full article >>Beware the fees on Europe’s budget airlines, how to make a perfect summer <b>feast,</b> skin cancer is on the rise in young women and other consumer-focused news from The New York Times.    <br> The engineers of the SRT division have created a <b>tuner</b> edition of the 300, adding a raging bull of a Hemi engine that Rockford and Mannix would have loved.<br> My spouse and I are expecting a newborn <b>soon,</b> so we spent last weekend <a href = "http://buyz19.tumblr.com/forex-growth-bot">forex growth bot </a> aisles of a big-box baby supply store.<br> I couldn't help but feel that buying all this new gear is unnecessary. Can't we<br><img src="http://1.bp.blogspot.com/-9UqIcP_QCd4/Tr_D_JbXnEI/AAAAAAAAAjk/oY2ghE5zVkw/s1600/Rory-Gilmore-gilmore-girls-34512_766_1024.jpg"><br> just use our friends' and families' <b>old</b> baby stuff? <b>--</b> Today is Tuesday, March 15, the 74th day of 2011. There are 291 days left in the year. <b>O2</b> and BE customers will soon be transferred on to a Sky service, but past transfer fiascos loom largeHome phone and broadband customers <b>of</b> both O2 and BE, who have officially became customers of Sky, are facing a <b>nervous</b> wait to <b>see</b> what this means in the long term <b>for</b> the service they receive <b>and</b> how much they pay.Sky<br> announced in March that it had bought O2's home phone and broadband business from the mobile operator's parent company Telefonica.<br> The £200m deal affected 500,000 households,<br><img src="http://cdn.ph.upi.com/sv/i/UPI-2001362084569/2013/1/13620869041786/Westminster-show-dog-murder-mystery.jpg"><br> and included customers of BE broadband, acquired by O2 last year.Affected <b>households</b> will be hoping Sky can avoid a repeat of the botched TalkTalk takeovers of <b>Tiscali</b> and AOL that caused endless disputes, and eventually led to the regulator <b>Ofcom</b> levying heavy fines.The move means there is now less competition in the phone broadband market, which <b>is</b> dominated by four firms: BT, Sky, TalkTalk and Virgin.Sky is keen to reassure customers of O2 and BE <b>that</b> there will not be a repeat of the Tiscali fiasco. It says it will be honouring the terms of all current O2 contracts, <b>and</b> that the migration, which will not start until August, will be phased in. It says when the switchover takes place<br><img src="http://hartfordmag-survey.wehaaserver.com/imgs/media.images/25/best-of-hartford-square.jpg"><br> customers will <b>lose</b> their connections for just a few minutes, and they will be given plenty of warning beforehand.Once all the old O2 contracts have <b>expired</b> Sky plans to have every<br><img src="http://2.bp.blogspot.com/_Ry9kRyd7QYc/TUkRqQNJ0MI/AAAAAAAABRU/CurpLaPhqFw/s1600/600px-Fart.svg.png"><br> phone/broadband customer paying the same, with customers coming <b>off</b> <b>their</b> existing O2 contract automatically being offered the equivalent Sky deal. Any customers <b>who</b> are out of contract, and who don't wish to join Sky, can switch now or at the end of their deal in the normal way."We'll<br> start moving O2 and BE home broadband and phone <b>customers</b> over to our state-the-art network starting from autumn.<br> We'll be in touch with customers at every step way and will work in partnership with O2 to ensure it's a smooth process," <b>says</b> a spokeswoman.According to our comparison of all three tariffs, customers should notice<br><img src="http://animal.discovery.com/tv/a-list/creature-countdowns/myths/images/dog.jpg"><br> few changes when they<br><img src="http://aucklandmtb.files.wordpress.com/2012/05/womens-rides.jpg"><br> are moved on to Sky's package. <a href = "http://buyz19.tumblr.com/aquaponics-4-you">aquaponics 4 you review </a> customers <b>will</b> pay £15 a month if they don't take a calls package, and will have to move to direct debit payments to avoid a £4 <b>a</b> month credit card <b>surcharge.However,<br></b> Sky's Anytime calls package includes free<br><img src="http://cdn.idolator.com/wp-content/uploads/2012/12/26/foxes-best-music-2012-600x450.jpg"><br> calls to 0870 numbers but omits those to the 0845 numbers now used by lots <b>of</b> banks and insurers' call centres.Those who pay Sky for its TV package, but had used O2<br><img src="http://postnoon.com/wp-content/uploads/2012/09/dog_days_in_hyderabad_postnoon_news.jpg"><br> for their phone and broadband, could see their total monthly bill fall by a <b>few</b> <b>pounds.The</b> big question for many is what this will do for service standards.<br> When TalkTalk took over AOL and <b>Tiscali</b> <b>it</b> led to billing problems and number of disputes with customers over promises made by the previous company.Marie-Louise<br> Abretti, telecoms expert at uSwitch.com, says customers will be concerned about how Sky handles the transition. "Following TalkTalk's takeover of <b>Tiscali</b> in 2009, Ofcom <b>hit</b> the providers with £3m in fines for wrongly <b>billing</b> customers, mainly caused by problems with integrating accounts. It's vital that Sky learns from this and ensures consumers don't<br><img src="http://pic.epicfail.com/wp-content/uploads/2012/11/epic-wtf-costume-fail.jpg"><br> lose out."She says Sky's "truly<br><img src="http://2.bp.blogspot.com/-D1Kuxdra8nI/UMX_uv6Q48I/AAAAAAAAABo/b3NdQbDtQi8/s1600/Pakistani-Girl-Punjab-Rung.jpg"><br> unlimited downloads with no traffic management" will have a big appeal to customers, but predicts that some O2 mobile customers may start shopping around <b>for</b> a better deal."While some customers will be worried about the hassle of finding a new provider, it could <b>be</b> a great opportunity for them to ensure they're getting the best broadband – and mobile – deal for their needs. For Sky TV <b>fans,</b> in particular, this could be a great time to bundle products, which can be cheaper and more convenient."New<br> customers don't have to worry that the company is underfunded. Sky this week reported pre-tax profits of £966m for the nine months <b>to</b> 31 March, up from £899m a year earlier.Internet,<br> phones & broadbandConsumer affairsBroadbandInternetTelecommunications <b>industryMiles</b> Brignallguardian.co.uk<br> © 2013 Guardian News and Media Limited or its <b>affiliated</b> companies. <b>All</b> rights reserved. | Use of this content is subject to our Terms & Conditions | More Feeds     For years, officials <b>in</b> wealthy, liberal Montgomery County have avoided difficult decisions on scaling back pensions and health-care benefits for retirees. Now, the long-term shortfall is $4.8 billion. Chris Smith was struck deeply by <b>the</b> death of his <b>Kris</b> <b>Kross</b> partner <b>Chris</b> Kelly earlier this week a[...] IN BENTIU, SUDAN At an oil field in southern Sudan's oil-rich Unity state, a tar-colored sludge flowed out of <a href = "http://buyz19.tumblr.com/trademiner">trademiner </a> of a truck into a man-made <b>pool.</b> European <b>Union</b> antitrust authorities raided the offices of major telecommunications companies this week in an inquiry into anticompetitive behavior.     <b>Computers</b> and cyborgs aren’t about to render the American worker obsolete. But they’re tilting the nation’s economy more and more in favor <b>of</b> the rich and away from the poor and the middle <b>class,</b> new economic research contends. Read full article >>     <b>ATLANTA</b> -- Gerald Grinstein took the helm of <b>Delta</b> Air Lines at an age when <b>many</b> chief executives have given up the corner office for leisurely days of fly fishing or sailing. He stepped in at the urging <b>of</b> Delta's board in 2004 to help rescue the reeling <b>airline</b> -- battered by problems in the la... Many of the poems in Roberto Bolaño’s “Unknown University” were written <b>when</b> he was in his 20s, the sound of a promising young writer seeking his way in the world of words.     The Department of Homeland Security has given up on one of its broadest anti-terrorism data-mining tools after investigators found it was tested with information about real people without the required privacy safeguards. <b>Authorities</b> in central Mexico say a clash between security forces and gunmen armed with AR-15 rifles and grenades left 10 assailants dead.<br> The <b>court</b> ruled that owners of goods from overseas can do what they like <b>with</b> them, <b>just</b> as they can with those bought in the United States. Even taxpayers who are exempt<br><img src="http://images.nationalgeographic.com/wpf/media-live/photos/000/015/cache/afghan-girl-portrait_1563_990x742.jpg"><br> from the federal<br><img src="http://i.dailymail.co.uk/i/pix/2013/01/18/article-2264718-17057EAC000005DC-65_634x491.jpg"><br> tax on estates under the American Taxpayer Relief Act may <b>be</b> wise to study how the law affects their estate planning.     Whether an Oscar nominee's newfound recognition <b>in</b> Hollywood will pay off <b>in</b> future, lasting and top-billed work is a crapshoot. The operator of the crippled Japanese nuclear site found a rodent’s scorched body <b>inside</b> a switchboard and said the animal may have short-circuited it.<br> A study has<br><img src="http://photos.motogp.com/2012/11/11/girl_10_preview_big.jpg"><br> infused the field of cardiovascular medicine with optimism, as scientists are calling <b>for</b> similarly rigorous studies of other popular diets. Terence Nance writes, directs and<br><img src="http://animal.discovery.com/images/breed-selector/dogs/breeds/greater-swiss-mountain-dog_04_lg.jpg"><br> acts in “An Oversimplification of Her Beauty,” his film about the sweet romantic tension between two close friends.    <br> Actor Lindsay Lohan has escaped a jail sentence after accepting a plea bargain over charges arising from a car crash The U.S.<br> stock market barely reacted to the largest earthquake to ever hit Japan, as the level of damage from the disaster remained
  • trends shaping IT hiring in

    Two peak-season fruits collaborate in this classic dessert.    <br> The John <b>F.<br></b> Kennedy Center for the Performing Arts <b>in</b> Washington announces its 2013-14 <b>season.Hollywood's</b> magical ball is Sunday <b>night,</b> <b>and</b> all week<br><img src="http://kreview.com/attachment.php%3Faid%3D11264"><br> television personalities have been fretting and squealing about it, expecting us to watch<br><img src="http://lovelystationery.com/wp-content/uploads/2012/06/lovely-stationery-wtp3.jpg"><br> in supportive awe, like Cinderella. Imagine a drug that could whittle your waistline, control blood pressure, keep <b>you</b> regular, protect your heart, strengthen your bones, cut the risk of stroke and possibly help you sidestep some types of cancer. <b>And</b> <b>what</b> if this drug were also easy to obtain and inexpensive, and it even tasted good? The Pittsburgh Steelers don't think they'll find an impact player <b>with</b> the 17th pick in this week's draft.    <br> The nominee, Enrico Letta, deputy head of the Democratic Party, said he would consult with the <b>country’s</b> leaders about <b>its</b> “fragile and unprecedented” political situation.<br> MIT Media Lab Professor Tod Machover discusses his robotic opera, Death and the Powers.Video:<br> Paula Aguilera/Jonathan Williams/Nobuyuki Ueda/Yolanda Spínola Elías; additional footage/stills: Melanie GonickThis creative fusion of music and technology could reposition opera as an art form that embraces innovation, says Marc Scorca, president and CEO of Opera America, a nonprofit that serves U.S.<br> opera companies.<br> He <b>notes</b> that for hundreds <b>of</b> years, opera was known<br><img src="http://images2.fanpop.com/image/photos/9000000/Lovely-Baby-Girl-sweety-babies-9050432-450-344.jpg"><br> for welcoming innovation<br><img src="http://images2.fanpop.com/image/photos/14400000/Pretty-Little-Liars-Cast-Instyle-Makeover-Shoot-hanna-marin-14429238-500-632.jpg"><br> through new technologies and instrumentation.<br> But that role was usurped in the late 19th <b>century</b> when film<br><img src="http://s1.ibtimes.com/sites/www.ibtimes.com/files/styles/v2_article_large/public/2013/02/20/twodogs.jpg"><br> emerged as the most innovative art <b>form;</b> <b>opera</b> appeared staid in comparison.“I’m always cheering <b>when</b> I see opera once again reasserting itself as the richest tapestry for innovative, live art,” Scorca says.Not<br><img src="http://25.media.tumblr.com/tumblr_m7dkzchxth1rbc3mlo1_500.gif"><br> only does Scorca consider Death and the Powers <b>to</b> be groundbreaking because it tests the “definitional boundaries” of opera, but <a href = "http://buyz19.tumblr.com/tinnitus-miracle">tinnitus miracle review </a> <b>notes</b> how rare it is for an opera to be conceived and produced outside the <b>framework</b> of<br><img src="http://kreview.com/attachment.php%3Faid%3D11264"><br> a traditional opera company. The fact that Machover’s group at the Media Lab produced Death and the Powers “shows <b>opera’s</b> potent viability as a medium that has creative potential for anyone who is innovating in interdisciplinary art,” he says.While<br> Scorca hopes that the use of technology in Death and the Powers will inspire other operas, Machover cautions that it will be some time before the opera’s influence is clear — either within the world of opera or beyond. He notes that many of his larger endeavors have had unexpected results, such as his audience-interactive Brain Opera, which yielded <b>many</b> <b>of</b> the technologies behind the Guitar Hero video game. Although Machover believes that <b>techniques</b> like disembodied performance will influence how emotions are captured and communicated in performances, he thinks that a major impact of Death and the Powers will be through its story and music. “‘Powers’ is packed with vivid melodies, quirky rhythms and pungent textures that I <b>hope</b> might stick in <b>the</b> ear, stir the imagination and resonate in unexpected ways,” he says.<br> Raiders linebacker Kaluka Maiava and his brother Ilima were charged with assaulting two men at a bar in Hawaii.    <br> Roger Clemens' former personal trainer arrived at the U.S. Attorney's Office Friday for a day-long meeting with prosecutors about his former client's alleged drug use.<br> The decision to hold a stand-alone event reflected the company’s emphasis on interactive entertainment, including chats and playing along with a game show at home.     In Washington, lobbyists who had <b>long</b> backed Republicans are also focusing on Democrats to build coalitions against a medical device tax.<br><img src="http://4.bp.blogspot.com/_tafXqu5xBBE/THNa74KTxpI/AAAAAAAAAKg/v8XH5NISmwM/s1600/SadFace.jpg"><br> Arcade <a href = "http://buyz19.tumblr.com/forex-growth-bot">forex growth bot download </a> set up shop at DFA Records' New York City studio owned by former LCD Soundsyst[...] One day after President Obama submitted his budget request for fiscal 2012 to Capitol Hill, <b>congressional</b> Republicans<br><img src="http://images2.fanpop.com/image/photos/9000000/Lovely-Baby-Girl-sweety-babies-9050432-450-344.jpg"><br> assailed the document as too weak on spending.<br> But they also signaled an openness <b>to</b> <b>working</b> with Democrats to solve the nation's financial problems.<br> After they re-signed defenseman Ryan McDonagh, the Rangers will now try to negotiate with forwards Derek Stepan and Carl Hagelin.    <br> On a trip to Tunisia and Egypt, Secretary of State Hillary Rodham Clinton was dogged by questions about looming crises in Libya and other countries where <b>democratic</b> aspirations have been met with brute force. Bruce Springsteen and Pete Seeger <b>are</b> among 198 new members elected to the American Academy of Arts [...] Last week, Interior Design raised a glass to Stone Source, which celebrated the official opening of its new showroom <b>and</b> warehouse in New York. Northern Ireland's Graeme McDowell and U.S.<br> Open champion Webb Simpson took the RBC Heritage into a sudden-death playoff <b>at</b> Hilton Head Island in South Carolina on Sunday.     For all the continued chatter this morning about the sincerity and limits of presidential schmoozing, the real reason for the fiscal impasse is hiding right there in plain sight, and it can be summed up in two sentences: Read full article >> Spain striker Jese scored in injury time as his team came from behind to beat Mexico, 2-1, in Istanbul to set up a quarterfinal against Uruguay at the Under-20 World Cup.    <br> The line between what's real and what's not is thin and shifting, and the U.S.<br> Department of Homeland Security has decided to explore both sides.<br> Boldly going where few <a href = "http://buyz19.tumblr.com/aquaponics-4-you">aquaponics 4 you download </a> have gone before, the agency is enlisting the expertise of science fiction writers. Many thoughts flash through a <b>woman’s</b> mind on the eve of a double mastectomy — most prominently fears about her mortality. But in the thicket of complicated emotions that crowded Laurel Kamen’s brain as she sat in her Kalorama apartment contemplating her diagnosis of breast cancer, <b>she</b> also had to reckon with fretfulness about her future wardrobe. Read <b>full</b> article >> When cells suffer too much DNA damage, they are usually forced to undergo programmed cell death, or apoptosis. However, cancer cells often ignore these signals, flourishing even after chemotherapy drugs <b>have</b> ravaged their DNA.A new finding <b>from</b> MIT researchers may offer a way to overcome that resistance: The team has identified a key protein involved in an alternative death pathway known as programmed necrosis.<br> Drugs that mimic the effects of this protein could push cancer cells that are resistant to apoptosis into necrosis instead.While apoptosis is a tightly controlled procedure that breaks <b>down</b> <b>and</b> disposes of the dying <b>cell</b> in a <b>very</b> orderly <b>way,</b> necrosis is a messier process <b>in</b> which the cell’s membrane <b>ruptures</b> and its contents spill out.“People really used to think of necrosis as cells just falling apart, that it wasn’t programmed and didn’t require gene products to make it happen,” says Leona Samson, a member of MIT’s Center for Environmental Health Sciences and Koch Institute for <b>Integrative</b> Cancer Research.<br> “In the last few years <b>it</b> has become more clear <b>that</b> this is an active process that requires <b>proteins</b> to take place.”In the May 10 online edition of the journal Genes and Development, Samson and colleagues report <b>that</b> a protein <b>known</b> as<br><img src="http://d364y98vz4769w.cloudfront.net/drawings/images/000/001/102/full/FART.jpg%3F1334133373"><br> <b>ALKBH7</b> <a href = "http://buyz19.tumblr.com/trademiner">trademiner </a> <b>key</b> role in controlling the programmed <b>necrosis</b> pathway. Dragony Fu, a former postdoc in Samson’s lab, is the paper’s lead author,<br><img src="http://static.ddmcdn.com/gif/pug.jpg"><br> and postdoc Jennifer Jordan is also an author.Unexpected findingsALKBH7 belongs to a family of proteins first discovered in E. coli about a dozen years ago as part <b>of</b> a DNA-repair mechanism.<br><img src="http://cdn.motinetwork.net/motifake.com/image/demotivational-poster/0809/hilarious-hilarious-air-guitar-idiot-retard-cat-demotivational-poster-1220603476.jpg"><br> In humans, there are nine different ALKBH proteins, which Samson’s <b>lab</b> has been studying for several years.Most<br> of the mammalian ALKBH proteins appear to be involved in <b>DNA</b> repair, <b>similar</b> to the original E.<br> coli version. In particular, they respond to DNA damage caused by alkylating agents. These agents can be found in <b>pollutants</b> <b>such</b> as fuel exhaust and tobacco smoke, and are also used to treat cancer.In<br> the<br><img src="http://media.kval.com/images/Cruz%2Bthe%2Bdog1.jpg"><br> <b>new</b> paper, Samson, a professor of biology and biological engineering, and her colleagues found that ALKBH7 has an <b>unexpected</b> effect. When <b>the</b> researchers lowered ALKBH7 levels in human cells grown in the lab, those cells <b>were</b> much more likely <b>to</b> survive DNA damage than cells with normal ALKBH7 levels. This suggests that ALKBH7 actually promotes cell death.“That<br> was a surprising finding, because previously all of these ALKBH proteins were shown to be helping <b>the</b> cell survive when exposed to damage,” says Fu, who is now a visiting research fellow at the University of <b>Zurich.Upon</b> <b>further</b> investigation, the researchers found <b>that</b> <b>when</b> healthy cells suffer <b>massive</b> DNA damage from alkylating agents, they<br><img src="http://4.bp.blogspot.com/_tafXqu5xBBE/THNa74KTxpI/AAAAAAAAAKg/v8XH5NISmwM/s1600/SadFace.jpg"><br> enter the programmed necrosis pathway. Necrosis, which can also be initiated <b>by</b> bacterial or viral infection, is believed to help the body’s immune system detect threats.“When dying cells release their contents during necrosis, it serves as a warning signal for your body that there is a virus there <a href = "http://buyz19.tumblr.com/natural-vitiligo-treatment">natural vitiligo treatment download </a> macrophages and other immune cells to the area,” Fu says.Potential<br> drug targetsThe findings suggest that when DNA <b>is</b> so badly harmed that cells can’t repair it, the programmed necrosis pathway kicks in to prevent cells with major genetic damage from potentially become cancerous. Other researchers have shown that some types of cancer cells have much lower <b>ALKBH7</b> levels than<br><img src="http://graphics8.nytimes.com/images/2012/12/25/t-magazine/25best-culture/25best-culture-tmagArticle.jpg"><br> normal cells. This suggests that the cancer cells have gained the ability <b>to</b> evade programmed necrosis, helping them <b>to</b> survive, Fu says.The necrosis pathway appears to be initiated by an<br><img src="http://files.sharenator.com/rappers_rappers_pokemon_soulja_boy_funny_hilarious_ouch_gros_demotivational_poster_1250306507-s640x682-81737.jpg"><br> enzyme called <b>PARP,</b> which becomes hyperactive following DNA damage and shuts down the cell’s production of two molecules that carry energy, ATP and NAD.<br> The MIT team found that ALKBH7 prevents ATP and NAD levels from returning to<br><img src="http://funnybonecentral.com/ComicImage/84b1eea2-d6b1-4a35-8207-0be7d2939066/6db1ce6f-097d-4ebf-b14e-f0f1a521cd89/320/510/Y/N"><br> normal <b>by</b> disrupting the function of mitochondria — the <b>cell</b> structures that generate energy for a cell.<br> Without an adequate supply of those critical <b>energy-carrying</b> <b>molecules,</b> the <b>cell</b> cannot survive and undergoes necrosis.<br> In cells that lack ALKBH7, ATP and NAD levels rebound, and the cells survive, carrying a heavy burden of DNA damage.The researchers are now investigating the molecular <b>details</b> of the programmed necrosis pathway in hopes of<br><img src="http://cdn.sheknows.com/articles/2010/11/A_Baby_girl.jpg"><br> identifying ways to activate it in cancer cells. “The observations reported in this paper open up the possibility that novel treatments <b>could</b> be developed to treat tumors that are relatively resistant to killing via the apoptotic pathway,”<br><img src="http://mimg.sulekha.com/telugu/lovely/stills/lovely-stills-0265.jpg"><br> says Ashok Bhagwat, a professor of chemistry at Wayne State University who was not part of the research team.The research was funded by the National Institutes of Health and the American Cancer Society. The Ruth Lilly Poetry <b>Prize</b> for lifetime achievement will <b>go</b> to Ms. Ponsot,